Amafutha e-Ylang-ylang

I-Ylang-ylangamafutha abalulekile (YEO), atholakala ezimbalini zesihlahla esishisayoCanangaiphungaIhuku. f. & Thomson (umndeniI-Annonaceae), isetshenziswe kakhulu emithini yendabuko ngokusetshenziswa okuningi, okuhlanganisa ukukhathazeka kanye nezimo ze-neuronal ezishintshiwe. Ubuhlungu be-neuropathic yisimo esibuhlungu esingapheli esinezimo eziphezulu ze-comorbidities, njengokukhathazeka, ukucindezeleka, nokunye ukuphazamiseka kwemizwelo, okuthinta kakhulu izinga lempilo yesiguli. Izidakamizwa ezitholakalayo okwamanje ezisetshenziselwa ukuphatha ubuhlungu be-neuropathic azanele ngenxa yokungasebenzi kahle kanye nokubekezelelana, okugqamisa isidingo somuthi we-pharmacotherapy engcono. Ucwaningo oluningana lwemitholampilo lubike ukuthi ukubhucungwa noma ukuhogela ngamafutha abalulekile akhethiwe kunciphisa izimpawu ezihlobene nobuhlungu nokukhathazeka.

Inhloso yalolu cwaningo bekuwukuphenya izakhiwo ze-analgesicYEOkanye nempumelelo yayo ekwehliseni ukuguquka kwemizwelo okuhlobene ne-neuropathy.

Izakhiwo ze-analgesic zahlolwa kumodeli yokulimala kwenzwa elondoloziwe kusetshenziswa amagundane abesilisa. Izakhiwo ze-anxiolytic, antidepressant, kanye nelocomotor nazo zahlolwa kusetshenziswa ukuhlolwa kokuziphatha. Ekugcineni, indlela yokusebenza ye-YEO yaphenywa entanjeni yomgogodla kanye ne-hippocampus yamagundane e-neuropathic.

Ukuphathwa ngomlomo kweYEO(I-30 mg/kg) inciphise ubuhlungu be-neuropathic obubangelwa i-SNI futhi ithuthukisa izimpawu zokukhathazeka ezihlobene nobuhlungu ezivele ezinsukwini ezingu-28 ngemva kokuhlinzwa.YEOyehlise ukuvezwa kwama-MAPK, i-NOS2, i-p-p65, omaka be-neuroinflammation, futhi yathuthukisa umphumela wokujwayelekile kumazinga we-neurotrophin.

YEOokudalwe ukukhululeka kobuhlungu be-neuropathic kanye nokukhathazeka okuhlobene nobuhlungu, okumelela ikhandidethi elithakazelisayo lokuphatha izimo zobuhlungu be-neuropathic kanye ne-comorbidities ehlobene nobuhlungu.