I-OEM Custom Package Natural Macrocephalae Rhizoma oil

incazelo emfushane:

Njenge-ejenti ye-chemotherapeutic ephumelelayo, i-5-fluorouracil (5-FU) isetshenziswa kabanzi ekwelapheni izimila eziyingozi emgudwini wamathumbu, ikhanda, intamo, isifuba, nesibeletho. Futhi i-5-FU umuthi womugqa wokuqala womdlavuza we-colorectal emtholampilo. Indlela yokusebenza ye-5-FU ukuvimbela ukuguqulwa kwe-uracil nucleic acid ibe yi-thymine nucleic acid kumaseli e-tumor, bese ithinta ukuhlanganiswa nokulungiswa kwe-DNA ne-RNA ukufeza umphumela wayo we-cytotoxic (Afzal et al., 2009; Ducreux et. al., 2015; Longley et al., 2003). Kodwa-ke, i-5-FU iphinde ikhiqize isifo sohudo esibangelwa ngamakhemikhali (CID), enye yezindlela ezimbi ezivame kakhulu ezihlupha iziguli eziningi (Filho et al., 2016). Isigameko sohudo ezigulini eziphathwe nge-5-FU safika ku-50% -80%, okwathinta kakhulu inqubekelaphambili nokusebenza kwe-chemotherapy (Iacovelli et al., 2014; Rosenoff et al., 2006). Ngakho-ke, kubaluleke kakhulu ukuthola ukwelashwa okusebenzayo kwe-CID eyenziwe yi-5-FU.

Njengamanje, ukungenelela okungezona izidakamizwa kanye nokungenelela kwezidakamizwa kuye kwangeniswa ekwelashweni komtholampilo kwe-CID. Ukungenelela okungezona izidakamizwa kufaka phakathi ukudla okulungile, nokwengeza ngosawoti, ushukela nezinye izakhamzimba. Izidakamizwa ezifana ne-loperamide ne-octreotide zivame ukusetshenziswa ekwelapheni okulwa nesifo sohudo kwe-CID (Benson et al., 2004). Ukwengeza, ama-ethnomedicines nawo ayamukelwa ukwelapha i-CID ngokwelashwa kwawo okuhlukile emazweni ahlukahlukene. Umuthi wendabuko waseShayina (TCM) ungomunye we-ethnomedicine ojwayelekile osewenziwe iminyaka engaphezu kuka-2000 emazweni aseMpumalanga Asia ahlanganisa i-China, Japan kanye neKorea (Qi et al., 2010). I-TCM ithi izidakamizwa ze-chemotherapeutic zingabangela ukusetshenziswa kwe-Qi, ukuntula ubende, ukungezwani kwesisu kanye nomswakama we-endophytic, okuholela ekungasebenzi kahle kwamathumbu. Kuthiyori ye-TCM, isu lokwelapha le-CID kufanele lincike ikakhulukazi ekwengezeni i-Qi nokuqinisa ubende (Wang et al., 1994).

Izimpande ezomisiwe zeI-Atractylodes macrocephalaKoidz. (AM) kanyeI-Panax ginsengCA Mey. (PG) imithi yendabuko ejwayelekile ku-TCM enemiphumela efanayo yokwengeza i-Qi nokuqinisa ubende (Li et al., 2014). I-AM ne-PG ivamise ukusetshenziswa njengepheya yamakhambi (uhlobo olulula lokuhambisana namakhambi aseShayina) nemiphumela yokwengeza i-Qi kanye nokuqinisa ubende ukwelapha isifo sohudo. Isibonelo, i-AM ne-PG zabhalwa kumafomula asendulo okulwa nesifo sohudo njenge-Shen Ling Bai Zhu San, Si Jun Zi Tang evela.Taiping Huimin Heji Ju Fang(Uzalo Lwengoma, China) kanye noBu Zhong Yi Qi Tang abavelaUPi Wei Lun(Ubukhosi bakwaYuan, China) (Umdwebo 1). Ucwaningo oluningi lwangaphambilini lwalubike ukuthi wonke la mafomula amathathu anamandla okunciphisa i-CID (Bai et al., 2017; Chen et al., 2019; Gou et al., 2016). Ngaphezu kwalokho, ucwaningo lwethu lwangaphambilini lubonise ukuthi iShenzhu Capsule equkethe kuphela i-AM ne-PG inemiphumela engaba khona ekwelapheni isifo sohudo, i-colitis (xiexie syndrome), nezinye izifo zesisu (Feng et al., 2018). Kodwa-ke, alukho ucwaningo oluxoxile ngomthelela nendlela ye-AM ne-PG ekwelapheni i-CID, kungaba yinhlanganisela noma yodwa.

Manje i-gut microbiota ithathwa njengento engaba yisici ekuqondeni indlela yokwelapha ye-TCM (Feng et al., 2019). Ucwaningo lwesimanje lukhombisa ukuthi i-gut microbiota idlala indima ebalulekile ekugcineni i-homeostasis yamathumbu. I-Healthy gut microbiota inomthelela ekuvikelweni kwe-mucosal yamathumbu, i-metabolism, i-immune homeostasis kanye nokuphendula, kanye nokucindezelwa kwe-pathogen (Thursby noJuge, 2017; Pickard et al., 2017). I-microbiota ye-gut ephazamisekile ikhubaza imisebenzi yomzimba kanye neyomzimba womuntu ngokuqondile noma ngokungaqondile, idala ukusabela okusemaceleni okufana nesifo sohudo (Patel et al., 2016; Zhao noShen, 2010). Ucwaningo lubonise ukuthi i-5-FU yashintsha ngokuphawulekayo ukwakheka kwe-gut microbiota kumagundane ohudo (Li et al., 2017). Ngakho-ke, imiphumela ye-AM ne-PM kuhudo olubangelwa yi-5-FU ingase ixoxwe yi-gut microbiota. Kodwa-ke, ukuthi i-AM ne-PG iyodwa futhi ihlangene ingavimbela isifo sohudo esibangelwa yi-5-FU ngokushintsha i-gut microbiota akwaziwa.

Ukuze kuphenywe imiphumela elwa nesifo sohudo kanye nendlela eyisisekelo ye-AM ne-PG, sisebenzise i-5-FU ukuze silingise imodeli yohudo kumagundane. Lapha, sigxile emiphumeleni engaba khona yokuphatha okukodwa nokuhlanganisiwe (AP) yeI-Atractylodes macrocephalaamafutha abalulekile (AMO) kanyeI-Panax ginsengisamba sama-saponins (PGS), izingxenye ezisebenzayo ngokulandelana ezikhishwe ku-AM ne-PG, kuhudo, ukugula kwamathumbu kanye nesakhiwo se-microbial ngemva kokwelashwa ngamakhemikhali kwe-5-FU.