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I-Wholesale Pure Natural Atractylodes Amafutha e-Lancea Amafutha e-Daily Chemical Industry Herb Extract Atractylis Oil
IMIBANDELA YOKUSEBENZISA NOLWAZI OLUBALULEKILE: Lolu lwazi lwenzelwe ukwengeza, hhayi esikhundleni seseluleko sikadokotela wakho noma umhlinzeki wezempilo futhi aluhloselwe ukumboza konke ukusetshenziswa okungenzeka, izinyathelo zokuphepha, ukusebenzisana noma imiphumela emibi. Lolu lwazi lungase lungalingani nezimo zakho zempilo ezithile. Ungalokothi ulibale noma ungakunaki ukufuna iseluleko sezokwelapha kudokotela wakho noma omunye umhlinzeki wezempilo oqeqeshiwe ngenxa yento oyifundile ku-WebMD. Kufanele ngaso sonke isikhathi ukhulume nodokotela wakho noma uchwepheshe wezokunakekelwa kwempilo ngaphambi kokuba uqale, ume, noma ushintshe noma iyiphi ingxenye enqunyiwe yohlelo lwakho lokunakekelwa kwezempilo noma ukwelashwa futhi unqume ukuthi iyiphi inkambo yokwelapha ekulungele.
Lokhu okuqukethwe okune-copyright kuhlinzekwa yi-Natural Medicines Comprehensive Database Consumer Version. Ulwazi oluvela kulo mthombo lusekelwe ebufakazini futhi lunenjongo, futhi alunawo umthelela wezohwebo. Ukuze uthole ulwazi lwezokwelapha oluchwepheshile ngemithi yemvelo, bheka Inguqulo Ephelele Yedatha Yemithi Yezemvelo.
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I-Wholesale Pure Natural Atractylodes Amafutha e-Lancea Amafutha e-Daily Chemical Industry Herb Extract Atractylis Oil
Iyini i-Atractylodes lancea root extract?
I-Atractylodes lancea ingumsuka waseShayina, isitshalo esiwusizo kwezokwelapha, esilinyelwa ama-rhizomes aso. Ama-rhizomes ayo aqukethe amafutha abalulekile.
Ukusetshenziswa Nezinzuzo:
Inezinto ezilwa nokuvuvukala, ithambisa isikhumba uma isetshenziswa. Kungase kube usizo esikhumbeni esithandwa yizinduna, esicasukile.
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Okuqukethwe kwamafutha e-Menthol CamphorBorneol Okugeza kanye Ne-Aromatherapy
Izinzuzo Zezempilo kanye Nokusetshenziswa
I-Borneol inikeza ukuhlangana okuzuzisa kakhulu kwemithi yaseNtshonalanga neyaseMpumalanga. Umphumela we-Borneol usakazekile ekwelapheni izifo ezihlukahlukene. Emithi yaseShayina, ihlotshaniswa nesibindi, i-spleen meridians, inhliziyo, namaphaphu. Ngezansi kunohlu lwezinye zezinzuzo zayo eziningi zezempilo.
Ilwa nesifo sokuphefumula kanye nesifo samaphaphu
Ucwaningo oluningi luphakamisa i-terpenes, kanye ne-Borneol, ikakhulukazi, ukunciphisa ngempumelelo ukugula kokuphefumula. I-Borneol ineukhombise ukusebenza kahleekunciphiseni ukuvuvukala kwamaphaphu ngokunciphisa ama-cytokines avuthayo kanye nokungena okuvuthayo. Abantu abasebenzisa i-Chinese Medicine bavame ukusebenzisa i-Borneol ukwelapha i-bronchitis kanye nezifo ezifanayo.
Izakhiwo ze-Anticancer
I-Borneol nayo ibonisileizakhiwo ze-anticancerngokwandisa isenzo se-Selenocysteine (SeC). Lokhu kunciphisa ukusabalala komdlavuza ngokufa kwamaseli omdlavuza we-apoptotic (ohleliwe). Ezifundweni eziningi, i-Borneol iphinde yakhombisa ukusebenza kahle kweukuqondiswa kwezidakamizwa ze-antitumor.
I-analgesic esebenzayo
Phakathi kufundakucatshangelwa ubuhlungu be-postoperative kubantu, isicelo se-topical Borneol siholele ekunciphiseni ubuhlungu obukhulu uma kuqhathaniswa neqembu lokulawula i-placebo. Ukwengeza, ama-acupuncturists avame ukusebenzisa i-Borneol phezulu ngezakhiwo zayo zokuqeda ukuvuvukala.
Isenzo sokulwa nokuvuvukala
I-Borneol inekubonisiweukuvimbela iziteshi ezithile ze-ion ezikhuthaza ukugqugquzela ubuhlungu nokuvuvukala. Iphinde isize ekunciphiseni ubuhlungu ezifweni ezivuthayo ezifanaisifo samathambo.
Imiphumela ye-Neuroprotective
I-Borneol inikeza isivikelo esithile kusukaukufa kwamaseli we-neuronaluma kwenzeka kuba ne-ischemic stroke. Iphinde yenze kube lula ukuvuselelwa kwezicubu zobuchopho nokulungisa. Kuhlongozwa ukuthi kube nalo mphumela we-neuroprotective ngokushintsha ukungena kwe-umgoqo wegazi-ubuchopho.
Ilwa nokucindezeleka nokukhathala
Abanye abasebenzisi bezinhlobo ze-cannabis ezinamazinga aphezulu e-Borneol baphakamisa ukuthi yehlisa amazinga abo okucindezeleka futhi inciphise ukukhathala, ngaleyo ndlela, ivumele isimo sokuphumula ngaphandle kokudakwa okugcwele. Abantu abenza Imithi YaseShayina nabo bayavumaamandla ayo okunciphisa ukucindezelekal.
Umthelela wokuhlangana
Njengamanye ama-terpenes, imiphumela ye-Borneol ngokuhlanganiswa nama-cannabinoids e-cannabis ikhombisile.umphumela we-entourage.Lokhu kwenzeka lapho ama-compounds esebenza ndawonye ukuze anikeze inzuzo eyengeziwe yokwelapha. I-Borneol ingakhuphula ukugcwala kwesithiyo segazi nobuchopho, ivumele ukudlula kalula kwama-molecule okwelapha ohlelweni lwezinzwa olumaphakathi.
Ngaphandle kwemikhiqizo eminingi yokwelapha ye-Borneol, ibuye isetshenziswe ngokujwayelekile ezintweni ezixosha izinambuzane ngenxa yobuthi bayo bemvelo kuzimbungulu eziningi. Amakha aphinde asebenzise i-Borneol ngephunga layo elimnandi kubantu.
Izingozi Ezingenzeka kanye Nemiphumela Emibi
I-Borneol ivame ukubhekwa njenge-terpene yesibili ku-cannabis, okusho ukuthi ivela ngamanani amancane uma kuqhathaniswa. Le mithamo ephansi ye-Borneol kucatshangwa ukuthi iphephile uma kuqhathaniswa. Kodwa-ke, ngemithamo ephezulu engayodwa noma ukuchayeka isikhathi eside, i-Borneol ingaba nokunyeizingozi ezingaba khona kanye nemiphumela engemihle, okuhlanganisa:
- Ukucasuka kwesikhumba
- Ukucasuka kwekhala nomphimbo
- Ikhanda elibuhlungu
- Isicanucanu nokuhlanza
- Isiyezi
- Ikhanda elilula
- Ukuquleka
Ngokuchayeka okuphezulu kakhulu kwe-Borneol, abantu bangathola:
- Ukungahlaliseki
- Ukuyaluza
- Ukunganaki
- Ukuquleka
- Uma igwinywe, ingaba yingozi kakhulu
Kubalulekile ukuqaphela ukuthi inani elikhona ku-cannabis cishe ngeke libangele lezi zimpawu. Ukucasuka futhi akwenzeki ngemithamo emincane uma kuqhathaniswa esetshenziselwa i-analgesia neminye imiphumela.
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Amafutha e-Cnidii Fructus ahlanzekile ekhandlela nensipho enza i-wholesale diffuser uwoyela obalulekile ube musha wama-diffuser okushisa umhlanga
I-Cnidium isitshalo esidabuka eChina. Iphinde yatholakala e-US e-Oregon. Isithelo, imbewu, nezinye izingxenye zezitshalo zisetshenziswa njengomuthi.
I-Cnidium isetshenziswe eMithini Yendabuko YamaShayina (TCM) izinkulungwane zeminyaka, ngokuvamile ezimweni zesikhumba. Akumangazi ukuthi i-cnidium iyisithako esivamile kuma-lotions aseShayina, okhilimu, namafutha okugcoba.
Abantu bathatha i-cnidium ngomlomo ukuze bakhulise ukusebenza kocansi kanye nentshisekelo yocansi, kanye nokwelapha ukungasebenzi kahle kwe-erectile (ED). I-Cnidium iphinde isetshenziselwe ubunzima bokuba nezingane (ukungabi nabantwana), ukwakha umzimba, umdlavuza, amathambo abuthakathaka (i-osteoporosis), kanye nezifo zefungal kanye ne-bacterial. Abanye abantu bayayithatha ukuze bandise amandla.
I-Cnidium isetshenziswa ngqo esikhumbeni ukuze kulume, ukuqubuka, i-eczema kanye nezikelemu.
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Amafutha ephunga elimnandi enziwe nge-Branded ahlanzekile ekhandlela kanye nensipho enza i-wholesale diffuser uwoyela obalulekile usha wama-diffuser okushisa umhlanga
Ukwakhiwa kwamakhemikhali kwe-ATR
Ukwakheka kwamakhemikhali e-ATR ikakhulukazi yizingxenye eziguquguqukayo kanye nezingxenye ezingaguquki. Amafutha abalulekile e-ATR (ATEO) athathwa njengengxenye esebenzayo ye-ATR, futhi okuqukethwe kwe-ATEO kuwukuphela kwenkomba yokunqunywa kokuqukethwe kwe-ATR. Njengamanje, kukhona ucwaningo oluhlukahlukene mayelana nezingxenye eziguqukayo kanye nocwaningo oluncane kakhulu ngezingxenye ezingaguquki. Izingxenye eziguquguqukayo ziyinkimbinkimbi, futhi izinhlobo eziyinhloko zesakhiwo ziyi-phenylpropanoids (i-phenylpropanoids elula, i-lignans ne-coumarins) ne-terpenoids (i-monoterpenes, i-sesquiterpenes, i-diterpenoids ne-triterpenes). Izingxenye ezingaguquguquki ikakhulukazi ama-alkaloid, ama-aldehyde nama-asidi, ama-quinone nama-ketone, ama-sterol, ama-amino acid, nama-carbohydrate. Imiphumela yocwaningo lokwakheka kwamakhemikhali e-ATR izofaka isandla ekuthuthukisweni kocwaningo lwayo lwekhwalithi.
Ukwakheka okuguquguqukayo
Abacwaningi basebenzise amasu okuhlola okuhlaziya njenge-chromatography ne-GC-MS ukuze bahlaziye izingxenye zamakhemikhali ze-ATR ezivela emisuka ehlukene, amaqoqo ahlukene, izindlela ezihlukene zokukhipha nezingxenye ezihlukene. Ucwaningo lwangaphambilini lubonise ukuthi izakhi zamakhemikhali eziyinhloko ku-ATR kwakungamafutha aguquguqukayo, okuyinkomba ebalulekile yokuhlolwa kwekhwalithi ye-ATR. I-α-Asarone kanye ne-β-asarone ibalwe ku-95% wamafutha aguquguqukayo e-ATR futhi akhonjwe njengezingxenye zesici (Umfanekiso 1) (Lam et al., 2016a). I-“Pharmacopoeia of The People’s Republic of China” (Ushicilelo lwango-2020) ibhala ukuthi okuqukethwe kukawoyela okuguquguqukayo kwe-ATR akufanele kube ngaphansi kuka-1.0% (mL/g). Njengamanje, izinhlobo eziningi zezingxenye zikawoyela eziguqukayo zitholwe ku-ATR
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Amafutha ephunga elimnandi enziwe nge-Branded ahlanzekile ekhandlela kanye nensipho enza i-wholesale diffuser uwoyela obalulekile usha wama-diffuser okushisa umhlanga
I-Perilla iyikhambi. Iqabunga nembewu kusetshenziselwa ukwenza umuthi.
I-Perilla isetshenziselwa ukwelapha isifuba somoya. Ibuye isetshenziselwe ukucanuzela kwenhliziyo, ukushaywa yilanga, ukujuluka, kanye nokunciphisa ukuqina kwemisipha.
Ekudleni, i-perilla isetshenziswa njengesinongo.
Ekukhiqizeni, uwoyela wembewu ye-perilla usetshenziselwa ukuhweba ekukhiqizeni amavarnish, odayi, noyinki.
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Amafutha ephunga elimnandi enziwe nge-Branded ahlanzekile ekhandlela kanye nensipho enza i-wholesale diffuser uwoyela obalulekile usha wama-diffuser okushisa umhlanga
U-Angelica uyisitshalo. Impande, imbewu, nesithelo kusetshenziselwa ukwenza umuthi.
I-Angelica isetshenziselwa isilungulela, igesi yamathumbu (i-flatulence), ukulahlekelwa ukudla (i-anorexia), isifo samathambo, izinkinga zokujikeleza kwegazi, "ikhala eligijimayo" (i-catarrh yokuphefumula), ukwesaba, isifo, kanye nenkinga yokulala (ukuqwasha).
Abanye besifazane basebenzisa i-angelica ukuze baqale ukuya esikhathini. Ngezinye izikhathi lokhu kwenziwa ukuze kukhishwe isisu.
I-Angelica iphinde isetshenziselwe ukwandisa ukukhiqizwa komchamo, ukuthuthukisa isifiso sobulili, ukugqugquzela ukukhiqizwa nokuphuma kwe-phlegm, nokubulala amagciwane.
Abanye abantu bagcoba i-angelica ngqo esikhumbeni ngenxa yobuhlungu bezinzwa (neuralgia), ubuhlungu bamalunga (rheumatism), nokuphazamiseka kwesikhumba.
Ngokuhambisana namanye amakhambi, i-angelica nayo isetshenziselwa ukwelapha ukuqhanyelwa ngaphambi kwesikhathi.
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100% Amafutha Ahlanzekile E-Herbal Essential Cyperus Wensipho Ukwenza I-Cyperus Rotundus Amafutha
I-Nutgrass iyikhambi elidumile elisetshenziswa kuzo zonke izinhlobo zokunakekelwa kwesikhumba ezisebenzayo. Njengokwe-Ayurveda, isetshenziswe kuma-concoctions ahlukahlukene alungiselelwe ukukhanyisa amabala amnyama njll.
Izinzuzo...
Iphinde yatholakala emithini eminingi ye-Ayurvedic yokwelapha ukuqubuka, izifo zesikhunta kanye nezimo zesikhumba. Izingcaphuno eziyimpuphu zempande ye-Nutgrass zinamandla amakhulu futhi zinothiswe ngama-antioxidants, okusiza ukwehlisa ukuguga kwesikhumba njengoba kusebenza ukwehlisa imigqa emihle nemibimbi. Kuyasiza ukulawula ukwakheka ngokweqile kwe-pigment, i-melanin, esikhumbeni. Ngaleyo ndlela ibuyisela ibala elikhanyayo lesikhumba. I-Nutgrass iyaphola ngokwemvelo, impahla yayo eqeda ukuvuvukala isiza ukudambisa ububomvu, ukuqubuka, kanye nesikhumba esivuvukele. Ifakazele ukwelapha izimo zesikhumba ezinzima. Icebile ngama-fatty acids, amavithamini nama-flavonoid azuzisa kakhulu isikhumba kanye nezinwele. Lezi zakhiwo zengeza ekukhanyeni kwesikhumba, futhi ziqinisa izinwele ngokukhanya nomthamo.
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Amafutha emvelo ahlanzekile e-Notopterygium aphezulu asetshenziselwa ukunakekelwa kwezempilo
Mayelana nokukhipha umoya nokuqeda ubumanzi, kunamakhambi amaningi aseShayina afanelekayo. Ngakho-ke, ukuqhathanisa i-notopterygium nontanga bayo abanezakhiwo ezifanayo zokuphulukisa kungasisiza ukuba sisiqonde kangcono lesi sitshalo somuthi.
Kokubili impande ye-notopterygium kanye ne-Angelica Root (Du Huo) ingasusa ukuswakama komoya futhi ithuthukise ubuhlungu bamalunga nokuqina. Kodwa banamandla abo kanye nobuthakathaka babo ngokulandelana. Eyokuqala inemvelo enamandla kanye nokunambitheka okuqinile, okuyenza ibe nomthelela ongcono we-antipyretic ngokujuluka kanye namandla akhuphukayo. Ngaleso sizathu, iyimifino efanelekile yezifo zomgogodla kanye nobuhlungu emzimbeni ongaphezulu nangemuva kwekhanda. Uma kuqhathaniswa, impande ye-angelica ine-potency eyehlayo, eyinikeza amandla angcono okuphulukisa ku-rheumatism yomzimba ophansi kanye nobuhlungu obuhlangene ezinyaweni, emhlane ophansi, emlenzeni nase-shin. Ngenxa yalokho, zivame ukusetshenziswa ngambili emithini yokwelapha njengoba zihambisana kakhulu.
Kokubili i-notopterygium kanyeU-Gui Zhi (Ramulus Cinnamomi)zikwazi ukuxosha umoya nokususa amakhaza. Kodwa lowo wangaphambili ukhetha ukumanzisa komoya ekhanda, entanyeni, nasemuva ngenkathiUGu Zhikungcono ukubhekana nomoya-umswakama emahlombe, izingalo, neminwe.
Bothe notopterygium futhiI-Fang Feng (Radix Saposhnikoviae)zikhethekile ekuxosheni umoya. Kepha okokuqala kunomphumela onamandla kunoFang Feng.
Izenzo zesimanje ze-pharmacological ze-notopterygium root
1. Umjovo wawo unemiphumela ye-analgesic ne-antipyretic. Ngaphezu kwalokho, inokuvimbela isikhunta sesikhumba kanye ne-brucellosis;
2. Ingxenye yayo encibilikayo inomphumela wokuhlola wokulwa nokungezwani komzimba;
3. Amafutha ayo aguquguqukayo nawo anemiphumela yokulwa nokuvuvukala, i-analgesic kanye ne-antipyretic. Futhi ingamelana ne-pituitrin-induced myocardial ischemia futhi yandise ukugeleza kwegazi okunomsoco we-myocardial;
4. Uwoyela wayo oguquguqukayo usavimbela ukuzwela kohlobo olubambezelekile kumagundane.Isampula yezindlela zokupheka ze-notopterygium incisum kumakhambi e-herbal
U-Zhong Guo Yao Dian (i-Chinese pharmacopoeia) ukholelwa ukuthi i-acrid futhi iyababa ngokunambitheka kanye nemvelo efudumele. Imboza ama-meridians esinyeni nezinso. Imisebenzi eyinhloko ukuxosha umoya, ukuqeda amakhaza, ukususa umswakama, nokukhulula ubuhlungu. Ukusetshenziswa okuyisisekelo kwe-notopterygium kanye nezinkomba zifakaikhanda elibuhlunguohlotsheni olubandayo komoyaumkhuhlane ojwayelekile, i-rheumatism, nobuhlungu obubuhlungu ehlombe nasemhlane. Umthamo onconyiwe usuka ku-3 kuye ku-9 amagremu.
1. Qiang HuoFu ZiU-Tang ovela ku-Yi Xue Xin Wu (Izambulo Zezokwelapha). Ihlanganiswe ne-Fu Zi (I-Aconite),Gan Jiang(Ujinja OmisiweUmsuka), kanye noZhiGan Cao(Honey Fried Licorice Root) ukwelapha ubuchopho obuhlaselwe igciwane elibandayo langaphandle, ubuhlungu bobuchopho obuphuma emazinyweni, ezithweni ezibandayo, nomoya opholile ophuma emlonyeni nasemakhaleni.
2. Jiu Wei Qiang Huo Tang kusukelaCi ShiNan Zhi (Ulwazi Olunzima). Yakhiwe ngeFang Feng, Xi Xin (Herba Asari),Chuan Xiong(lovage impande), njll. ukwelapha ukutheleleka kwangaphandle kohlobo olubandayo komoya okuhambisana nokuswakama, ukugodola, imfiva, akukho ukujuluka, ikhanda elibuhlungu,intamo eqinile, nobuhlungu bamalunga abukhali ezithweni.
3. I-Qiang Huo Sheng Shi Tang evela ku-Nei Wai Shang Bian Huo Lun (Icacisa Ukungabaza Ngokulimala Okuvela Ezimbangela Zangaphakathi Nezangaphandle). Isetshenziswa kanye nezimpande ze-angelica,Gao Ben(i-Rhizoma Ligustici), i-Fang Feng, njll. ukuphulukisa ukuphuma komoya kwangaphandle, ikhanda elibuhlungu kanye nenkanu eqinile ebuhlungu, iqolo elibuhlungu elisindayo, kanye nobuhlungu obuhlangene bomzimba wonke.
4. UJuan Bi Tang, owaziwa nangokuthi i-notopterygium kanyei-turmericinhlanganisela, evela ku-Bai Yi Xuan Fang (Imiyalelo ekhethwe Ngokuqondile). Isebenza noFang Feng, Jiang Huang (Curcuma Longa),Dang Gui(Dong Quai), njll. ukuqeda i-arthralgia ebanda komoya endaweni engaphezulu, ubuhlungu obuhlangene behlombe nezitho.
5. I-Qiang Huo Gong Gao Tang evela ku-Shen Shi Yao Han (Incwadi Ewusizo YezincwadiI-Ophthalmology). Ihlangana nempande ye-lovage,Bayi Zhi(Angelica Dahurica), i-Rhizoma Ligustici, njll. ukukhulula ikhanda elibuhlungu elibangelwa ukubanda komoya noma ukuswakama komoya.
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Amafutha e-lappa e-Aucklandia ahlanzekile ekhandlela nensipho enza i-wholesale diffuser uwoyela obalulekile ube masha emishini yokushisa umhlanga
I-Osteoarthritis (OA) ingesinye sezifo ezihlala isikhathi eside eziwohlokayo zamathambo ezithinta abantu abadala abangaphezu kweminyaka engama-65 [1]. Ngokuvamile, iziguli ze-OA kutholakala ukuthi zine-cartilage eyonakele, i-synovium evuthayo, nama-chondrocyte agugulekile, okubangela ubuhlungu nokucindezeleka ngokomzimba [2]. Ubuhlungu be-arthritis bubangelwa kakhulu ukuwohloka koqwanga emalungeni ngenxa yokuvuvukala, futhi lapho uqwanga lonakele kakhulu amathambo angashayisana abangele ubuhlungu obungabekezeleleki nobunzima bomzimba [3]. Ukubandakanyeka kwabalamuli abavuvukalayo abanezimpawu ezinjengobuhlungu, ukuvuvukala, nokuqina kwelunga kubhalwe kahle. Ezigulini ze-OA, ama-cytokines avuvukalayo, abangela ukuguguleka kwe-cartilage ne-subchondral bone atholakala ku-synovial fluid [4]. Izikhalazo ezimbili ezinkulu iziguli ze-OA ezivame ukuba nazo ubuhlungu nokuvuvukala kwe-synovial. Ngakho-ke imigomo eyinhloko yezindlela zokwelapha ze-OA zamanje ukunciphisa ubuhlungu nokuvuvukala. [5]. Nakuba izindlela zokwelapha ze-OA ezitholakalayo, okuhlanganisa nezidakamizwa ezingezona eze-steroidal kanye ne-steroidal, ziye zafakazela ukuthi ziyasebenza ekudambiseni ubuhlungu nokuvuvukala, ukusetshenziswa kwesikhathi eside kwale mithi kunemiphumela emibi kakhulu yezempilo njengokungasebenzi kahle kwenhliziyo, i-gastro-intestinal, kanye nezinso [6]. Ngakho-ke, umuthi osebenza ngempumelelo onemiphumela engemihle embalwa kufanele uthuthukiswe ukwelapha i-osteoarthritis.Imikhiqizo yezempilo yemvelo iya ngokuya iduma ngokuphepha nokutholakala kalula [7]. Imithi yendabuko yaseKorea ifakazele ukuthi iyasebenza ekulweni nezifo eziningana ezivuvukalayo, kuhlanganise nesifo samathambo [8]. I-Aucklandia lappa DC. yaziwa ngezici zayo zokwelapha, njengokuthuthukisa ukujikeleza kwe-qi ukuze kudambise izinhlungu nokupholisa isisu, futhi isetshenziswe ngokwesiko njenge-analgesic yemvelo [9]. Imibiko yangaphambilini iphakamisa ukuthi i-A. lappa ine-anti-inflammatory [10,11], i-analgesic [12], umdlavuza [13], kanye ne-gastroprotective [14] imiphumela. Imisebenzi ehlukahlukene yezinto eziphilayo ye-A. lappa ibangelwa izinhlanganisela zayo ezinkulu ezisebenzayo: i-costunolide, i-dehydrocostus lactone, i-dihydrocostunolide, i-costuslactone, i-α-costol, i-saussurea lactone ne-costuslactone [15]. Ucwaningo lwangaphambilini luthi i-costunolide ibonise izakhiwo zokulwa nokuvuvukala ku-lipopolysaccharide (LPS), eyenza ama-macrophages ngokusebenzisa ukulawulwa kwe-NF-kB kanye nomzila weprotheyini wokushisa ukushisa [16,17]. Nokho, alukho ucwaningo oluphenye imisebenzi engaba khona ye-A. lappa yokwelashwa kwe-OA. Ucwaningo lwamanje luphenye imiphumela yokwelapha ye-A. lappa ngokumelene ne-OA kusetshenziswa (i-monosodium-iodoacetate) i-MIA namamodeli wamagundane enziwe nge-acetic acid.I-Monosodium-iodoacetate (MIA) isetshenziswa ngokudumile ukukhiqiza okuningi kokuziphatha kobuhlungu kanye nezici ze-pathophysiological ze-OA ezilwaneni [18,19,20]. Lapho ijova emalungeni amadolo, i-MIA iphazamisa i-chondrocyte metabolism futhi ibangele ukuvuvukala nezimpawu zokuvuvukala, njengokuguguleka kwe-cartilage kanye ne-subchondral bone, izimpawu eziyinhloko ze-OA [18]. Ukuphendula okubhaliwe okwenziwe nge-acetic acid kubhekwa kabanzi njengokulingisa ubuhlungu be-peripheral ezilwaneni lapho ubuhlungu obuvuthayo bungalinganiswa ngobuningi [19]. I-mouse macrophage cell line, i-RAW264.7, isetshenziswa kakhulu ukutadisha izimpendulo zamaselula ekuvuvukeni. Lapho kusebenze nge-LPS, ama-macrophage e-RAW264 avula izindlela zokuvuvukala futhi afihle abaxhumanisi abaningana abavuvukalayo, njenge-TNF-α, COX-2, IL-1β, iNOS, ne-IL-6 [20]. Lolu cwaningo luhlole imiphumela ephikisana ne-nociceptive ne-anti-inflammatory ye-A. lappa ngokumelene ne-OA kumodeli yezilwane ye-MIA, imodeli yezilwane eyenziwe nge-acetic acid, kanye namaseli e-RAW264.7 acushwe yi-LPS.2. Izinto kanye Nezindlela
2.1. Impahla Yezitshalo
Impande eyomile ye-A. lappa DC. okusetshenziswe ekuhloleni kuthengwe kwa-Epulip Pharmaceutical Co., Ltd., (Seoul, Korea). Yahlonzwa nguProf. Donghun Lee, uMnyango we-Herbal pharmacology, Col. of Korean Medicine, Gachon University, futhi inombolo yesampula yevawusha yafakwa ngokuthi 18060301.2.2. Ukuhlaziywa kwe-HPLC kwe-A. lappa Extract
I-A. lappa yakhishwa kusetshenziswa i-reflux apparatus (amanzi acwecwe, 3 h ku-100 °C). Isixazululo esikhishiwe sahlungwa futhi safinyezwa kusetshenziswa i-evaporator enengcindezi ephansi. I-A. lappa extract ibe nesivuno esingu-44.69% ngemva kokumiswa yiqhwa ngaphansi kokungu-−80 °C. Ukuhlaziywa kweChromatographic kwe-A. lappa kwenziwe nge-HPLC exhunywe kusetshenziswa i-1260 InfinityⅡ HPLC-system (Agilent, Pal Alto, CA, USA). Ngokuhlukaniswa kwe-chromatic, ikholomu ye-EclipseXDB C18 (4.6 × 250 mm, 5 µm, Agilent) isetshenziswe ku-35 °C. Isamba esingu-100 mg wesampula sihlanjululwe ku-10 mL we-methanol engu-50% futhi yafakwa i-sonication imizuzu engu-10. Amasampuli ahlungwa ngesihlungi sesirinji (Waters Corp., Milford, MA, USA) esingu-0.45 μm. Ukwakheka kwesigaba seselula bekuyi-0.1% phosphoric acid (A) ne-acetonitrile (B) futhi ikholomu yacaciswa kanje: 0–60 min, 0%; 60-65 amaminithi, 100%; 65–67 min, 100%; 67–72 min, 0% i-solvent B enezinga lokugeleza lika-1.0 mL/min. Ukungcola kubonwe ku-210 nm kusetshenziswa umthamo womjovo ongu-10 μL. Ukuhlaziya kwenziwe ngokuphindwe kathathu.2.3. Izindlu Zezilwane Nokuphathwa
Amagundane angama-Sprague–Dawley (SD) anamaviki angu-5 kanye namagundane angama-ICR anamaviki angu-6 athengwe kwaSamtako Bio Korea (Gyeonggi-do, Korea). Izilwane zazigcinwa ekamelweni kusetshenziswa izinga lokushisa elingaguquki (22 ± 2 °C) kanye nomswakama (55 ± 10%) kanye nomjikelezo wokukhanya/omnyama we-12/12 h. Izilwane zazijwayelene nalesi simo isikhathi esingaphezu kwesonto ngaphambi kokuba kuqale ukuhlolwa. Izilwane zazine-ad libitum supply yokuphakelayo namanzi. Imithetho yokuziphatha yamanje yokunakekelwa nokuphathwa kwezilwane e-Gachon University (GIACUC-R2019003) ilandelwe ngokuqinile kuzo zonke izinqubo zokuhlola izilwane. Ucwaningo lwenzelwe uphenyo oluphuphuthekiswe umphenyi noluhambisanayo. Silandele indlela yokubulala ngokweziqondiso zeKomidi Lokuziphatha Lokuhlola Izilwane.2.4. I-MIA Injection Nokwelashwa
Amagundane ahlukaniswa ngokungahleliwe abe amaqembu angu-4, okungukuthi sham, control, indomethacin, kanye ne-A. lappa. Njengoba ekhishwa izinzwa ngengxube ye-2% ye-isofluorane O2, amagundane ajovwa kusetshenziswa i-50 μL ye-MIA (40 mg/m; Sigma-Aldrich, St. Louis, MO, USA) intra-articularly emalungeni amadolo ukuze aholele ku-OA yokuhlola. Ukwelashwa kwenziwa ngezansi: amaqembu okulawula kanye nama-sham agcinwe kuphela nge-AIN-93G yokudla okuyisisekelo. Kuphela, iqembu le-indomethacin linikezwe i-indomethacin (3 mg/kg) ehlanganiswe nokudla kwe-AIN-93G kanye neqembu le-A. lappa 300 mg/kg labelwa ekudleni kwe-AIN-93G okungezwe nge-A. lappa (300 mg/kg). Ukwelashwa kwaqhutshekwa izinsuku ezingu-24 kusukela ngosuku lokungeniswa kwe-OA ngenani lika-15-17 g nge-190-210 g yesisindo somzimba nsuku zonke.2.5. Isisindo Sokuthwala
Ngemva kokufakwa kwe-OA, ukukalwa kwamandla okuthwala isisindo semilenze yangemuva yamagundane kwenziwa nge-incapacitance-MeterTester600 (IITC Life Science, Woodland Hills, CA, USA) njengoba kuhleliwe. Ukusatshalaliswa kwesisindo ezithweni zangemuva kubaliwe: umthamo wokuthwala isisindo (%) -
I-Chinese Angelica Dahurica I-Root Extract Amafutha Yokubhucunga
Ukusetshenziswa kwe-Angelica
Ukusetshenziswa kwezithasiselo kufanele kube okuqondene nomuntu ngamunye futhi kuhlolwe uchwepheshe wezokunakekelwa kwempilo, njengodokotela wezokudla obhalisiwe, usokhemisi, noma umhlinzeki wokunakekelwa kwezempilo. Asikho isithako esihloselwe ukwelapha, ukwelapha, noma ukuvimbela izifo.
Ubufakazi obuqinile besayensi obusekela ukusetshenziswa kwe-Angelica buyantuleka. Kuze kube manje, ucwaningo oluningi mayelanaAngelica archangelicayenziwe kumamodeli ezilwane noma ezindaweni zaselabhorethri. Sekukonke, kudingeka uvivinyo lwabantu okwengeziwe ngezinzuzo ezingaba khona ze-Angelica.
Okulandelayo ukubheka ukuthi ucwaningo olukhona luthini mayelana nokusetshenziswa kwe-Angelica.
I-Nocturia
I-Nocturiaisimo esichazwa njengesidingo sokuvuka ebuthongweni kanye noma ngaphezulu ubusuku ngabunye ukuze uchame. I-Angelica iye yafundelwa ukusetshenziswa kwayo ekudambiseni i-nocturia.
Ocwaningweni olulodwa oluyimpumputhe kabili, ababambiqhaza abane-nocturia ababelwe abesilisa lapho bezalwa bahlelwa ngokungahleliwe ukuze bathole noma yikuphii-placebo(into engasebenzi) noma umkhiqizo owenziwe nge-Angelica archangelicaiqabunga amasonto ayisishiyagalombili.4
Abahlanganyeli bacelwe ukuthi balandelele kumadayari uma benzawachama. Abacwaningi bahlole idayari ngaphambi nangemva kwesikhathi sokwelashwa. Ekupheleni kocwaningo, labo abathatha i-Angelica babika i-voids embalwa yasebusuku (isidingo sokuvuka phakathi nobusuku bayochama) kunalabo abathatha i-placebo, kodwa umehluko wawungabalulekile.4
Ngeshwa, zimbalwa ezinye izifundo ezenziwe ukuze kutholwe ukuthi i-Angelica ingayithuthukisa kakhulu i-nocturia. Ucwaningo olwengeziwe luyadingeka kule ndawo.
Umdlavuza
Nakuba singekho isithasiselo noma imifino engelaphekaumdlavuza, kunentshisekelo ethile ku-Angelica njengokwelashwa okuhambisanayo.
Abacwaningi baye bacwaninga ngemiphumela engaba khona yokulwa nomdlavuza ka-Angelica elebhu. Kolunye ucwaningo olunjalo, abacwaningi bahlolaAngelica archangelicakhipha kuumdlavuza webeleamaseli. Bathole ukuthi i-Angelica ingasiza ekubangeleni ukufa kwamangqamuzana omdlavuza webele, okuholela abacwaningi ekuphetheni ngokuthi kungenzeka ukuthi ikhambi libe naloi-antitumorokungenzeka.5
Ucwaningo oludala kakhulu olwenziwa kumagundane lwathola imiphumela efanayo.6 Nokho, le miphumela ayizange iphindwe ekuhlolweni kwabantu. Ngaphandle kokuhlolwa kwabantu, abukho ubufakazi bokuthi i-Angelica ingasiza ekubulaleni amangqamuzana omdlavuza womuntu.
Ukukhathazeka
I-Angelica isetshenziswe emithini yendabuko njengendlela yokwelaphaukukhathazeka. Nokho, ubufakazi besayensi obusekela lesi simangalo abutholakali.
Njengokunye ukusetshenziswa kwe-Angelica, ucwaningo mayelana nokusetshenziswa kwayo ekukhathazekeni lwenziwe kakhulu ezindaweni zelebhu noma kumamodeli ezilwane.
Kokunye ukuhlola, okukhishwe kwe-Angelica kwanikezwa amagundane ngaphambi kokuba enzeukucindezelekaizivivinyo. Ngokusho kwabacwaningi, amagundane enze kangcono ngemva kokuthola i-Angelica, okwenza kube ukwelashwa okungenzeka kube nokukhathazeka.7
Ukuhlolwa kwabantu nokucwaninga okunamandla kuyadingeka ukuze kutholakale indima engaba khona ka-Angelica ekwelapheni ukukhathazeka.
Izakhiwo ze-Antimicrobial
I-Angelica kuthiwa inezinto ezilwa namagciwane, kodwa izifundo zabantu eziklanywe kahle azikenziwa ukufakazela lesi simangalo.
Ngokusho kwabanye abacwaningi, i-Angelica ikhombisa umsebenzi we-antimicrobial ngokumelene ne-:2
- I-Clostridium difficile (C. diff)
- I-Clostridium perfringens
- I-Enterococcus faecalis
- I-Eubacterium limosum
- I-Peptostreptococcus anaerobius
- Candida albicans
Nokho, kunikezwe umongo omncane mayelana nendlela i-Angelica engase iwavimbele ngayo lawa kanye namanye amagciwane nesikhunta.
Okunye Ukusetshenziswa
Emithini yesintu,Angelica archangelicaisetshenziselwa ukwelapha izifo ezengeziwe, okuhlanganisa:1
Ubufakazi besayensi bekhwalithi obusekela lokhu kusetshenziswa bukhawulelwe. Qiniseka ukuthi ukhuluma nomhlinzeki wezempilo ngaphambi kokusebenzisa i-Angelica kulezi zimo zezempilo nezinye.
Iyini imiphumela emibi ye-Angelica?
Njenganoma iyiphi imifino noma i-supplement, i-Angelica ingabangela imiphumela emibi. Nokho, ngenxa yokuntuleka kokuhlolwa kwabantu, kuye kwaba nemibiko embalwa yemiphumela engemihle engase ibe khona ye-Angelica.
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Uwoyela wemvelo ohlanzekile we-organic magnolia obalulekile we-flos magnoliae wamafutha wamakha
I-Magnoliae Flos iyimithi yendabuko esetshenziswa kakhulu e-Asia. Isetshenziselwa ukwelapha i-sinusitis, ukucinana kwamakhala, kanye nesikhumba esizwela kakhulu. Ngenxa yokuthi i-Magonlia Flos yayichazwa njengento enephunga elimnandi emibhalweni yasendulo yamaShayina, sacabanga ukuthi uwoyela wayo obalulekile ungasetshenziswa ukwelapha izifo zokuzivikela komzimba. Amaseli e-Dendritic (DCs), athathwa njengenhloso enkulu yama-immunomodulators ukulawula izimpendulo zamasosha omzimba, adlala indima ebalulekile ekuphenduleni kokuzivikela komzimba okuguquguqukayo. Kulolu cwaningo, i-Magnoliae Flos amafutha abalulekile (MFEO) yehlisa ukukhiqizwa kwama-cytokines TNF- α, IL-6, kanye ne-IL-12p70 ku-lipopolysaccharide (LPS) -i-DCs evuselelwe. Iphinde yacindezela omaka bendawo i-MHC II, CD80, ne-CD86 kuma-DC avuselelwe i-LPS. Amamodeli ezilwane abonise ukuthi i-2,4-Dinitro-1-fluorobenzene (DNFB) eyenza impendulo yokuxhumana ne-hypersensitivity iye yavinjelwa ngemva kokwelashwa nge-MFEO. Ngaphezu kwalokho, i-MFEO ivimbele ukungena kwamaseli e-T ezindlebeni zamagundane enziwe yi-DNFB. Ukuhlola izinhlanganisela zayo ze-bioactive, izingxenye ze-MFEO zahlaziywa kusetshenziswa i-gas chromatography (GC) kanye ne-GC-mass spectrometry. Imiphumela yembula ukuthi izinhlanganisela ezinkulu ku-MFEO ziyi-camphor kanye ne-1,8-cineole. Ukuhlolwa okwengeziwe kwe-DC bioassays kuqinisekisile ukuthi lezi zinhlanganisela zicindezele kakhulu ukukhiqizwa kwe-cytokine kuma-DC enziwe yi-LPS. Ngakho-ke, sibonise ukuthi i-MFEO ibonisa umphumela we-immunosuppressive kokubili ku-vivo kanye ne-vitro, futhi i-camphor kanye ne-1,8-cineole ingase ibe izingxenye ezinkulu ezibhekene nekhono layo lokuzivikela komzimba. Okutholakele kukhomba ukuthi i-MFEO inamandla okwakhiwa njenge-immunosuppressant entsha yezifo ezeqile.
