Uwoyela wemvelo ohlanzekile we-organic magnolia obalulekile we-flos magnoliae wamafutha wamakha
I-Magnoliae Flos iyimithi yendabuko esetshenziswa kakhulu e-Asia. Isetshenziselwa ukwelapha i-sinusitis, ukucinana kwamakhala, kanye nesikhumba esizwela kakhulu. Ngenxa yokuthi i-Magonlia Flos yayichazwa njengento enephunga elimnandi emibhalweni yasendulo yamaShayina, sacabanga ukuthi uwoyela wayo obalulekile ungasetshenziswa ukwelapha izifo zokuzivikela komzimba. Amaseli e-Dendritic (DCs), athathwa njengenhloso enkulu yama-immunomodulators ukulawula izimpendulo zamasosha omzimba, adlala indima ebalulekile ekuphenduleni kokuzivikela komzimba okuguquguqukayo. Kulolu cwaningo, i-Magnoliae Flos amafutha abalulekile (MFEO) yehlisa ukukhiqizwa kwe-cytokines TNF-α” role=”presentation” style="box-sizing: border-box; isibonisi: emgqeni; ukuphakama komugqa: okuvamile; ukuhlukanisa amagama: okuvamile; ukuchichima-ukugoqa: evamile; indawo emhlophe: nowrap; ukuntanta: akukho; isiqondiso: ltr; ubuningi bobubanzi: akukho; ubude obukhulu: akukho; ububanzi obuncane: 0px; ubude obuncane: 0px; umngcele: 0px; i-padding: 0px; imajini: 0px; isikhundla: isihlobo;”>α
, IL-6, kanye ne-IL-12p70 ku-lipopolysaccharide (LPS) -ama-DC avuselelwe. Iphinde yacindezela omaka bendawo i-MHC II, CD80, ne-CD86 kuma-DC avuselelwe i-LPS. Amamodeli ezilwane abonise ukuthi i-2,4-Dinitro-1-fluorobenzene (DNFB) eyenza impendulo yokuxhumana ne-hypersensitivity iye yavinjelwa ngemva kokwelashwa nge-MFEO. Ngaphezu kwalokho, i-MFEO ivimbele ukungena kwamaseli e-T ezindlebeni zamagundane enziwe yi-DNFB. Ukuhlola izinhlanganisela zayo ze-bioactive, izingxenye ze-MFEO zahlaziywa kusetshenziswa i-gas chromatography (GC) kanye ne-GC-mass spectrometry. Imiphumela yembula ukuthi izinhlanganisela ezinkulu ku-MFEO ziyi-camphor kanye ne-1,8-cineole. Ukuhlolwa okwengeziwe kwe-DC bioassays kuqinisekisile ukuthi lezi zinhlanganisela zicindezele kakhulu ukukhiqizwa kwe-cytokine kuma-DC enziwe yi-LPS. Ngakho-ke, sibonise ukuthi i-MFEO ibonisa umphumela we-immunosuppressive kokubilinge vivofuthiku-vitro, kanye ne-camphor kanye ne-1,8-cineole ingase ibe izingxenye ezinkulu ezibhekene nekhono layo lokuzivikela komzimba. Okutholakele kukhomba ukuthi i-MFEO inamandla okwakhiwa njenge-immunosuppressant entsha yezifo ezeqile.