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imikhiqizo

Amafutha ephunga elimnandi enziwe nge-Branded ahlanzekile ekhandlela kanye nensipho enza i-wholesale diffuser uwoyela obalulekile usha wama-diffuser okushisa umhlanga

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Ukwakhiwa kwamakhemikhali kwe-ATR

Ukwakheka kwamakhemikhali e-ATR ikakhulukazi yizingxenye eziguquguqukayo kanye nezingxenye ezingaguquki. Amafutha abalulekile e-ATR (ATEO) athathwa njengengxenye esebenzayo ye-ATR, futhi okuqukethwe kwe-ATEO kuwukuphela kwenkomba yokunqunywa kokuqukethwe kwe-ATR. Njengamanje, kukhona ucwaningo oluhlukahlukene mayelana nezingxenye eziguqukayo kanye nocwaningo oluncane kakhulu ngezingxenye ezingaguquki. Izingxenye eziguquguqukayo ziyinkimbinkimbi, futhi izinhlobo eziyinhloko zesakhiwo ziyi-phenylpropanoids (i-phenylpropanoids elula, i-lignans ne-coumarins) ne-terpenoids (i-monoterpenes, i-sesquiterpenes, i-diterpenoids ne-triterpenes). Izingxenye ezingaguquguquki ikakhulukazi ama-alkaloid, ama-aldehyde nama-asidi, ama-quinone nama-ketone, ama-sterol, ama-amino acid, nama-carbohydrate. Imiphumela yocwaningo lokwakheka kwamakhemikhali e-ATR izofaka isandla ekuthuthukisweni kocwaningo lwayo lwekhwalithi.

Ukwakheka okuguquguqukayo

Abacwaningi basebenzise amasu okuhlola okuhlaziya njenge-chromatography ne-GC-MS ukuze bahlaziye izingxenye zamakhemikhali ze-ATR ezivela emisuka ehlukene, amaqoqo ahlukene, izindlela ezihlukene zokukhipha nezingxenye ezihlukene. Ucwaningo lwangaphambilini lubonise ukuthi izakhi zamakhemikhali eziyinhloko ku-ATR kwakungamafutha aguquguqukayo, okuyinkomba ebalulekile yokuhlolwa kwekhwalithi ye-ATR. I-α-Asarone kanye ne-β-asarone ibalwe ku-95% wamafutha aguquguqukayo e-ATR futhi akhonjwe njengezingxenye zesici (Umfanekiso 1) (Lam et al., 2016a). I-“Pharmacopoeia of The People’s Republic of China” (Ushicilelo lwango-2020) ibhala ukuthi okuqukethwe kukawoyela okuguquguqukayo kwe-ATR akufanele kube ngaphansi kuka-1.0% (mL/g). Njengamanje, izinhlobo eziningi zezingxenye zikawoyela eziguqukayo zitholwe ku-ATR


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  • Imininingwane Yomkhiqizo

    Omaka bomkhiqizo

    Acori TatarinowiiI-Rhizoma (ATR,Shi Chang PungesiShayina) i-rhizome eyomile yeI-Acorus tatarinowiiSchott., isitshalo esingapheli se-Araceae Juss (Yan et al., 2020b). Iqoshwa okokuqala emibhalweni yakudala yemithi yendabuko yamaShayina "i-Shen Nong's Materia Medica," futhi ifakwe ohlwini njengebanga eliphezulu. Imiphumela ye-ATR ngokuyinhloko iwukuvuselela, ukuthulisa ingqondo, ukuxazululashi(umswakama) futhi uvumelanise iwena(isisu) (Lam et al., 2016b). Ngokomtholampilo, i-ATR isetshenziselwa kakhulu ukuphazamiseka kwemizwa, isimiso senhliziyo, isimiso sokugaya ukudla kwamathumbu, uhlelo lokuphefumula eChina (Lam et al., 2016b;Li et al., 2018a) kanye nokwelapha isithuthwane, ukucindezeleka, amnesia, ukwazi, ukukhathazeka, ukuqwasha, aphasia, tinnitus, umdlavuza, ukuwohloka komqondo, unhlangothi, izifo zesikhumba, nezinye izifo eziyinkimbinkimbi (U-Lee et al., 2004;Liu et al., 2013;Lam et al., 2019;U-Li J. et al., 2021). Eminyakeni yamuva nje, ucwaningo lwayo lwe-pharmacological lubonise ukuthi i-ATR inemiphumela ehlukahlukene yezokwelapha, kuhlanganise ne-anti-epileptic, sedative, hypnotic, anti-convulsant, anti-tussive, anti-asthmatic, anti-oxidant, anti-tumor njalonjalo (Wu et al., 2015;Lam et al., 2017a;Fu et al., 2020;Shi et al., 2020;U-Zhang W. et al., 2022). Ucwaningo lwangaphambilini lubonise ukuthi i-ATR iyathembisa njengomuntu ongase abe yisidakamizwa ekwelapheni isifo i-Alzheimer's (AD), ukucindezeleka, noma i-ulcerative colitis. Uma kubhekwa ukusebenza kahle komtholampilo kwe-ATR kanye nokutholakala okuqhubekayo kwemisebenzi emisha yemithi kanye nezithako ezisebenzayo, bekulokhu kukhathazwa kabanzi emhlabeni wonke eminyakeni yamuva nje futhi sekungenye yezinhlobo zemithi yaseShayina ezicwaningiwe ezishisayo emkhakheni wezokwelapha.

    Ukwakheka kwamakhemikhali kanye nemiphumela ye-pharmacological ye-ATR kuye kwabikwa kabanzi emashumini ambalwa eminyaka adlule, futhi i-pharmacokinetics yayo kanye nobuthi nayo ifundwe ngamazinga ahlukahlukene. Kodwa-ke, imibiko eminingi yangaphambilini ihlakazekile, ayinakho isifinyezo esihlelekile kanye nokufakwa kwe-ATR. Ngakho-ke, lokhu kubuyekezwa kuhloswe ukunikeza isifinyezo esibanzi kanye nengxoxo yokwakheka kwamakhemikhali ayo, i-pharmacology, i-pharmacokinetics kanye nezici zobuthi, ngaleyo ndlela kube nesandla ekusebenzeni okuqhubekayo komtholampilo kanye nokusetshenziswa kwe-ATR.








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