I-Wholesale Pure Natural Atractylodes Amafutha e-Lancea Amafutha e-Daily Chemical Industry Herb Extract Atractylis Oil

I-Wholesale Pure Natural Atractylodes Amafutha e-Lancea Wezimboni Zansuku zonke Zezimboni zeHerb Extract Atractylis Oil Isithombe Esifakiwe

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I-pisthorchis viverrini (OV)-induced cholangiocarcinoma (CCA) umdlavuza ojwayelekile phakathi kwabesilisa nabesifazane, ikakhulukazi eThailand. Ucwaningo lwakamuva lubonise ukuthi ukukhishwa kwe-ethanol ye-AL kube nomphumela ovimbelayo kumodeli yezilwane ye-OV-induced CCA ngaphandle kobuthi obusobala ngokuphathwa ngomlomo izinsuku ezingu-30 ngokuvumelana nemiphumela evela ku-positron emission tomography-computed tomography kanye nama-hamster aseSyria abesilisa [7]. Ukuze uhlole umthelela we-AL rhizome ku-motility yamathumbu, amagundane alashwe nge-atropine-, dopamine-, kanye ne-5-hydroxytryptamine (5-HT) amukelwe ocwaningweni. Imiphumela iveze ukuthi ukukhishwa kwe-1 mg/kg kungacindezela kakhulu ukuphuma kwesisu okubangelwa yi-dopamine kanye nokwehla kwe-gastrointestinal motility ngomjovo we-intraperitoneal. Ukukhishwa ekugxilweni kuka-1000 mg/kg kungakhawulela ukuncipha kokunyakaza kwamathumbu amancane okubangelwa i-atropine, futhi okukhishwe komthamo ongu-500 mg/kg kungavimba ukuphuma kwesisu okubangelwa i-5-HT kanye nokuncipha kokuhamba kwamathumbu amancane [8]. Ukwengeza, i-AL isebenzise umphumela wokulwa nezilonda zesisu kumodeli yegundane ngokunciphisa abalamuli bokuvuvukala (okungukuthi i-tumor necrosis factor-α (TNF-α), i-interleukin-8 (IL-8), i-IL-6), ne-prostaglandin E2 (PGE2) kanye nokwandisa i-epidermal growth factor (EGF) kanye ne-trefoil factor2 (TFF2) [9]. Amagciwane esikhunta aphethwe emhlabathini anciphise isivuno samantongomane ngo-30%.10]. Muva nje, kubikwe ukuthi ukutshala ngokuhlanganyela namantongomane, i-AL ingase futhi icindezele izifo zesikhunta ezithwalwa emhlabathini ngokuvimbelaI-Fusarium oxysporumukukhula [11]. Ukukhishwa kwe-petroleum ether (PE) ku-AL kubonise umphumela ovimbelayo kumaseli omdlavuza wesisu womuntu we-BGC-823 kanye ne-SGC-7901. Ingxenyana ye-PE ingabangela i-apoptosis, ukuboshwa komjikelezo weseli, kanye nezinguquko ezingenzeka ze-mitochondrial transmembrane [12]. Umbiko wakamuva uveze ukuthi ukukhishwa kwe-MeOH kwe-AL kungavimbela ukukhiqizwa kwe-nitric oxide (NO) kumaseli e-lipopolysaccharide-stimulated murine macrophage-like RAW264.7 futhi kwenze ukukhishwa kwe-granulocyte-colony stimulating factor (G-CSF) kumaseli e-murine avamile we-colonic epithelial MCE301. CHA i-radical yamahhala [13]. Ukukhishwa kwe-ethanol kwe-AL kube nomthelela obalulekile wokuvinjelwa kwe-lipase nge-IC50 9.06 µg/mL ekuhlolweni kwe-lipase ye-pancreas yomuntu, futhi kubonise umphumela wokulwa nokukhuluphala kumodeli yamagundane okukhuluphala okubangelwa ukudla okunamafutha amaningi ekugxilweni okuphezulu kwama-500 mg. /kg [14]. Ukukhishwa kwamanzi okuvela ku-AL kubonise umsebenzi ophikisayo ngokumelene nama-serotonin receptors kanye nomphumela ovimbelayo ku-agonist ekhethiwe ye-5-HT2A/2C 1-(2,5-dimethoxy-4-iodophenyl) -2-aminopropane-induced head-twitch response kumagundane. [15]. Izingcaphuno zamanzi ezivela ku-AL zehlise ubuthi obubangelwa i-triptolide ngokulawulwa phansi kokuvezwa kwesibindi kwe-CYP3A. Okwamanje, i-AL ingathuthukisa imiphumela elwa nokuvuvukala ye-triptolide. Lokhu okutholakele kuphakamise ukuthi i-AL ingavimbela ubuthi futhi yandise umsebenzi wokwelapha we-triptolide ngokuhlanganiswa.